Diseño y simulación y comparación de controladores de concentración de glucosa en pacientes con diabetes tipo 1

Abstract

Type 1 diabetes is a chronic disease with highly mortality rates around the world, and its treatment is not already satisfactory, in consequence, they have a poor quality of life. In this dissertation work, an insulin treatment for regulation of blood glucose levels for type 1 diabetes patients is analyzed and compared through the classic controller, proportional integral derivative and a robust sliding mode control, based on Bergman’s minimal model and Roy & Parker’s exercise minimal model. A meal model is also presented as disturbances affecting the blood glucose. These model equations are used with nominal parameters, accepted values for describing patients with type 1 diabetes. The benefits of using this type control are shown, within which the system becomes insusceptible to parametric variation, between patients or for one. The results show that even though the parametric variation, the controller is able to maintain the blood glucose concentration into an acceptable range, known as normoglucemia, defined by the American Diabetes Association